The connection between physical and mental health is increasingly being acknowledged, which presents an opportunity to improve health outcomes and drive down the total cost of care. This more holistic understanding is emerging as disruptive market forces—such as legislative changes, expanded access, increased demand, limited provider supply, and a highly fragmented market—are creating both challenges and opportunities for innovation. Providers and payers must rise to the challenge and develop enduring strategies to meet the demands of emerging integrated care models, nontraditional partnerships, and value-based reimbursement.